alienate
Definitions
To cause someone to feel isolated or estranged from a group or activity.
To transfer the ownership of property rights to another person or group.
To make someone feel less friendly or sympathetic toward a person or cause.
Examples
His constant criticism served only to alienate his closest friends.
The new policy threatened to alienate the company's most loyal employees.
She felt that her radical political views would alienate her from her conservative family.