﹒To treat someone or something badly, cruelly, or unfairly.
﹒To handle or use something in a way that causes damage or deterioration.
﹒It is strictly against company policy to mistreat any of our employees.
﹒The animal shelter works tirelessly to rescue pets that have been mistreated by their previous owners.
﹒He felt guilty because he realized he had mistreated his friend during the argument.
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